Hepatotoxicity caused by the combined action of isoniazid and rifampicin.
نویسندگان
چکیده
A 35 year old black Somalian woman with miliary tuberculosis developed hepatotoxicity after a few days of treatment with isoniazid, rifampicin, pyrazinamide, and ethambutol. After withdrawal of all drugs the liver profile returned to normal and remained so after challenge with isoniazid. Hepatotoxicity recurred when rifampicin was added, but it was well tolerated when reintroduced without isoniazid.
منابع مشابه
Effect of cimetidine on hepatotoxicity induced by isoniazid-rifampicin combination in rabbits.
OBJECTIVE To evaluate the hepatoprotective potential of cimetidine in hepatotoxicity induced by isoniazid-rifampicin combination in albino rabbits. METHODS Six groups of six rabbits each were studied. Three groups received saline (control), isoniazid (50 mg/Kg/d) alone or isoniazid with rifampicin (100 mg/Kg/d) daily orally for 7 days. Other groups received intraperitoneal cimetidine (50 mg/K...
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ورودعنوان ژورنال:
- Thorax
دوره 50 2 شماره
صفحات -
تاریخ انتشار 1995